This hearty and flavorful John Wayne casserole is a perfect dish for family dinners or gatherings. Combining layers of seasoned ground beef, creamy sour cream mixture, and fresh vegetables, this casserole is not only delicious but also gluten-free, making it suitable for those with dietary restrictions.
When preparing this recipe, you might need to visit the supermarket for a few specific items. Ensure you have gluten-free bisquick mix, which is essential for the base layer. Additionally, diced tomatoes with green chilies add a unique flavor, so make sure to grab a can. The combination of sour cream and mayonnaise creates a creamy layer that complements the seasoned beef perfectly.

Ingredients For John Wayne Casserole Recipe
Ground beef: Provides the main protein and savory flavor for the casserole.
Taco seasoning: Adds a spicy and flavorful kick to the ground beef.
Sour cream: Contributes to the creamy layer, balancing the spices.
Mayonnaise: Adds richness and creaminess to the sour cream mixture.
Cheddar cheese: Shredded cheese that melts and adds a cheesy layer.
Diced tomatoes with green chilies: Provides a tangy and slightly spicy element.
Onion: Adds a sweet and savory flavor when chopped and layered.
Bell pepper: Adds a crunchy texture and fresh taste.
Gluten-free bisquick mix: Forms the base layer of the casserole, making it gluten-free.
Milk: Combines with the bisquick mix to create a batter.
Eggs: Helps bind the bisquick mixture and adds richness.
Technique Tip for This Recipe
When mixing the bisquick mix with milk and eggs, ensure that you whisk until there are no lumps for a smooth base layer. This will help the casserole bake evenly and create a consistent texture throughout.
Suggested Side Dishes
Alternative Ingredients
Ground beef - Substitute with ground turkey: Ground turkey is a leaner option and provides a similar texture and flavor profile.
Taco seasoning - Substitute with homemade taco seasoning: Homemade taco seasoning can be made with gluten-free spices like chili powder, cumin, paprika, garlic powder, onion powder, and oregano to ensure it is gluten-free.
Sour cream - Substitute with Greek yogurt: Greek yogurt is a healthier alternative that provides a similar creamy texture and tangy flavor.
Mayonnaise - Substitute with avocado mayo: Avocado mayo is a healthier, gluten-free option that offers a similar creamy consistency.
Cheddar cheese - Substitute with Daiya cheddar-style shreds: Daiya cheddar-style shreds are a dairy-free, gluten-free alternative that melts well and has a similar flavor.
Diced tomatoes with green chilies - Substitute with fresh tomatoes and green chilies: Fresh tomatoes and green chilies can be chopped and mixed to provide a fresher, gluten-free alternative.
Onion - Substitute with green onions: Green onions offer a milder flavor and can be used as a direct substitute in the same quantity.
Bell pepper - Substitute with poblano pepper: Poblano peppers provide a slightly different flavor with a bit more heat, adding a unique twist to the dish.
Gluten-free Bisquick mix - Substitute with almond flour and baking powder: Almond flour combined with baking powder can create a similar texture and is a great gluten-free alternative.
Milk - Substitute with almond milk: Almond milk is a dairy-free, gluten-free alternative that works well in baking and cooking.
Eggs - Substitute with flax eggs: Flax eggs (made from ground flaxseed and water) are a vegan, gluten-free alternative that can bind ingredients similarly to regular eggs.
Other Alternative Recipes Similar to This Dish
How To Store / Freeze This Recipe
- Allow the John Wayne Casserole to cool completely before storing. This helps prevent condensation, which can make the dish soggy.
- Transfer the casserole to an airtight container or cover the baking dish tightly with aluminum foil or plastic wrap.
- Store the casserole in the refrigerator for up to 3-4 days. Make sure to label the container with the date to keep track of freshness.
- For longer storage, consider freezing the casserole. Cut it into individual portions for easier reheating.
- Wrap each portion tightly in plastic wrap, then place the wrapped portions in a freezer-safe bag or container. This double-layer protection helps prevent freezer burn.
- Label the freezer-safe bag or container with the date and contents.
- The casserole can be frozen for up to 2-3 months. When ready to eat, thaw it in the refrigerator overnight.
- Reheat the thawed casserole in a preheated oven at 350°F (175°C) for about 20-25 minutes or until heated through. Cover with foil to prevent the cheese from over-browning.
- Alternatively, reheat individual portions in the microwave. Place a portion on a microwave-safe plate, cover with a microwave-safe lid or another plate, and heat on medium power for 2-3 minutes, checking and stirring halfway through.
How To Reheat Leftovers
- Preheat your oven to 350°F (175°C). Place the John Wayne Casserole in an oven-safe dish, cover it with aluminum foil to prevent it from drying out, and bake for about 20-25 minutes or until heated through. The cheddar cheese should be melted and bubbly again.
- If you're in a hurry, you can use the microwave. Place a portion of the casserole on a microwave-safe plate, cover it with a microwave-safe lid or another plate to retain moisture, and heat on medium power for 2-3 minutes. Check and stir halfway through to ensure even heating.
- For a crispier top, use a toaster oven. Preheat the toaster oven to 350°F (175°C), place a portion of the casserole on a toaster oven-safe tray, and heat for about 15-20 minutes. The cheddar cheese should be nicely melted and the edges slightly crispy.
- If you have an air fryer, preheat it to 350°F (175°C). Place a portion of the casserole in the air fryer basket, ensuring it's not overcrowded, and heat for about 10-12 minutes. This method will give you a crispy top layer while keeping the inside moist.
- For stovetop reheating, place a portion of the casserole in a non-stick skillet over medium heat. Cover with a lid and heat for about 10 minutes, stirring occasionally to prevent sticking and ensure even heating. This method works well if you want to avoid using the oven or microwave.
Best Tools for This Recipe
Skillet: Used to cook and brown the ground beef.
Mixing bowl: Needed to combine the sour cream, mayonnaise, and shredded cheese.
Mixing bowl: Another one is required to mix the bisquick mix, milk, and eggs.
Spatula: Handy for stirring and spreading mixtures.
Measuring cups: Essential for measuring out the sour cream, mayonnaise, cheddar cheese, bisquick mix, and milk.
Measuring spoons: Useful for measuring the taco seasoning if not using a pre-measured packet.
Can opener: Needed to open the can of diced tomatoes with green chilies.
Chopping board: Used for chopping the onions and bell peppers.
Knife: Essential for chopping the onions and bell peppers.
Baking dish: Used to layer and bake the casserole.
Oven: Preheated to 350°F (175°C) for baking the casserole.
Grater: Used to shred the cheddar cheese if not using pre-shredded cheese.
Colander: Useful for draining excess fat from the cooked ground beef.
Oven mitts: Important for safely handling the hot baking dish when removing it from the oven.
How to Save Time on Making This Recipe
Prepare ingredients ahead: Chop onions and bell peppers in advance. Pre-measure sour cream, mayonnaise, and cheese.
Use pre-cooked beef: Opt for pre-cooked ground beef to skip the browning step.
Mix dry ingredients early: Combine bisquick mix, milk, and eggs ahead of time.
Layer efficiently: Arrange all components in the order they will be used to streamline the layering process.
Preheat oven in advance: Ensure the oven is at the right temperature before starting.

John Wayne Casserole Recipe
Ingredients
Main Ingredients
- 1 lb Ground Beef
- 1 packet Taco Seasoning
- 1 cup Sour Cream
- 1 cup Mayonnaise
- 1 cup Cheddar Cheese, shredded
- 1 can Diced Tomatoes with Green Chilies
- 1 cup Onion, chopped
- 1 cup Bell Pepper, chopped
- 2 cups Bisquick Mix gluten-free
- 1 cup Milk
- 2 large Eggs
Instructions
- Preheat oven to 350°F (175°C).
- In a skillet, cook ground beef until browned. Drain excess fat. Add taco seasoning and water according to package instructions. Set aside.
- In a mixing bowl, combine sour cream, mayonnaise, and half of the shredded cheese. Set aside.
- In another bowl, mix Bisquick mix, milk, and eggs until well combined. Pour into a greased baking dish.
- Layer the cooked beef mixture over the Bisquick layer in the baking dish.
- Spread the sour cream mixture over the beef layer.
- Top with diced tomatoes, chopped onions, and bell peppers.
- Sprinkle the remaining shredded cheese on top.
- Bake in preheated oven for 30 minutes or until the top is golden and bubbly.
- Let it cool for a few minutes before serving.
Nutritional Value
Keywords
Suggested Appetizers and Desserts for This Recipe
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